Motif ID: NANOG{mouse}.p2

Z-value: 1.104


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
Nanog 71950 Nanog homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogchr6_+_1226575060.064.2e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_80421054 31.143 NM_016965
Nckap1
NCK-associated protein 1
chr7_+_138079669 21.749 NM_019564
Htra1
HtrA serine peptidase 1
chr9_-_7932402 21.411 Yap1
yes-associated protein 1
chr12_+_30687597 20.916 Pxdn
peroxidasin homolog (Drosophila)
chr1_-_194681914 17.507 NM_198247
Sertad4
SERTA domain containing 4
chr12_+_110782654 16.828 Meg3
maternally expressed 3
chr6_+_43215604 13.651 NM_133674
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr15_+_78258993 12.637 NM_001081367
Kctd17
potassium channel tetramerisation domain containing 17
chr14_+_51716032 12.131 Ang
Rnase4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family 4
chr9_-_31019412 11.827 Aplp2
amyloid beta (A4) precursor-like protein 2
chr12_+_80130149 11.815 NM_181073
Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr16_+_62854129 11.495 NM_011173
Pros1
protein S (alpha)
chr1_+_137635977 10.876 Csrp1
cysteine and glycine-rich protein 1
chr6_-_54543121 10.569 NM_153573
Fkbp14
FK506 binding protein 14
chr19_-_44476302 10.404 Scd1
stearoyl-Coenzyme A desaturase 1
chr2_+_121692687 10.219 NM_177054
NM_199038
Casc4

cancer susceptibility candidate 4

chr15_+_78858641 9.587 NM_008197
H1f0
H1 histone family, member 0
chr2_+_121692805 9.239 Casc4
cancer susceptibility candidate 4
chr9_+_72596925 9.233 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr14_+_30781514 9.041 NM_019979
Selk
selenoprotein K
chr18_+_35278553 8.984 NM_009818
Ctnna1
catenin (cadherin associated protein), alpha 1
chr4_-_58083082 8.877 Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr9_-_54509658 8.753 NM_053178
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr18_+_35278538 8.697 Ctnna1
catenin (cadherin associated protein), alpha 1
chr11_-_55209320 8.547 Sparc
secreted acidic cysteine rich glycoprotein
chr18_+_35278585 8.446 Ctnna1
catenin (cadherin associated protein), alpha 1
chr6_-_54543167 8.440 Fkbp14
FK506 binding protein 14
chr19_-_7292086 8.425 NM_007750
Cox8a
cytochrome c oxidase, subunit VIIIa
chr18_+_37644674 8.384 NM_053142
Pcdhb17
protocadherin beta 17
chr9_-_31019392 8.000 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr7_-_149763600 7.662 H19
H19 fetal liver mRNA
chr13_-_3803547 7.612 NM_027416
Calml3
calmodulin-like 3
chr6_+_124462638 7.388 NM_023143
C1ra
complement component 1, r subcomponent A
chr11_-_120685860 7.378 NM_007988
Fasn
fatty acid synthase
chr10_-_8605668 7.216 NM_175155
Sash1
SAM and SH3 domain containing 1
chr5_-_116858596 7.170


chr9_-_54509453 6.758 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr11_-_94902584 6.714 NM_133667
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr7_+_150255257 6.705 NM_001115085
NM_020285
NM_138631
Tssc4


tumor-suppressing subchromosomal transferable fragment 4


chr10_-_60610238 6.557 Sgpl1
sphingosine phosphate lyase 1
chr15_-_89004279 6.397 NM_001159521
Plxnb2
plexin B2
chr2_+_35111861 6.338 Gsn
gelsolin
chr7_+_147949708 6.304 NM_021282
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chrX_-_147248815 6.291 NM_030700
Maged2
melanoma antigen, family D, 2
chr1_-_36615225 6.253 NM_001126047
Sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr9_-_31019234 6.183 Aplp2
amyloid beta (A4) precursor-like protein 2
chr11_-_102680467 6.167 NM_001159382
Gjc1
gap junction protein, gamma 1
chr15_-_82991286 6.157 Cyb5r3
cytochrome b5 reductase 3
chr7_+_147949637 6.099 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr17_-_35019039 6.093 NM_013484
C2
complement component 2 (within H-2S)
chr5_-_124329899 6.013 NM_175520
Gpr81
G protein-coupled receptor 81
chr8_+_28134259 5.787 NM_153592
Erlin2
ER lipid raft associated 2
chr7_-_150646883 5.741 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_102680999 5.704 NM_001159383
Gjc1
gap junction protein, gamma 1
chr7_-_146101096 5.615 NM_009760
Bnip3
BCL2/adenovirus E1B interacting protein 3
chr5_-_145900858 5.546 Pdap1
PDGFA associated protein 1
chr1_-_82232392 5.300 Irs1
insulin receptor substrate 1
chr8_-_8661238 5.271 Efnb2
ephrin B2
chr13_-_23802696 5.232 Hfe
hemochromatosis
chr4_+_114761644 5.163 Pdzk1ip1
PDZK1 interacting protein 1
chr13_-_23802635 5.146 NM_010424
Hfe
hemochromatosis
chr5_-_44373000 5.113 NM_008009
Fgfbp1
fibroblast growth factor binding protein 1
chr6_+_124462696 5.101 C1ra
complement component 1, r subcomponent A
chr14_+_76904316 4.873 NM_009366
Tsc22d1
TSC22 domain family, member 1
chr2_+_84976516 4.862 NM_011784
Aplnr
apelin receptor
chr7_-_150646758 4.817 Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
chr11_-_116713532 4.813 Srsf2
serine/arginine-rich splicing factor 2
chr18_+_37828606 4.732 NM_033585
Pcdhga2
protocadherin gamma subfamily A, 2
chr10_-_126978704 4.712 Lrp1
low density lipoprotein receptor-related protein 1
chr15_+_58247016 4.605 NM_145959
D15Ertd621e
DNA segment, Chr 15, ERATO Doi 621, expressed
chr2_+_72244049 4.531 B230120H23Rik
RIKEN cDNA B230120H23 gene
chr4_+_118781405 4.489 Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
chr9_-_117539030 4.458 NM_001172121
Rbms3
RNA binding motif, single stranded interacting protein
chr10_-_83996516 4.390 Ckap4
cytoskeleton-associated protein 4
chr7_-_108025317 4.339 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr15_-_98783909 4.327 NM_011653
Tuba1a
tubulin, alpha 1A
chr4_+_118781336 4.305 NM_011400
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
chr15_+_78858872 4.295 H1f0
H1 histone family, member 0
chr9_-_56008595 4.282 Tspan3
tetraspanin 3
chr14_+_122580904 4.266 NM_029556
Clybl
citrate lyase beta like
chr15_+_78858900 4.179 H1f0
H1 histone family, member 0
chr10_+_97028456 4.137 Lum
lumican
chr5_+_67067359 4.105 NM_011670
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr19_-_44624857 4.102


chr14_-_65716932 4.091 NM_018788
Extl3
exostoses (multiple)-like 3
chr6_+_72548583 4.072 NM_026159
Retsat
retinol saturase (all trans retinol 13,14 reductase)
chr14_-_70919994 4.023 NM_009755
Bmp1
bone morphogenetic protein 1
chr15_-_102019373 3.981 Csad
cysteine sulfinic acid decarboxylase
chr6_-_82724366 3.931 NM_013820
Hk2
hexokinase 2
chr2_-_104334276 3.923 Hipk3
homeodomain interacting protein kinase 3
chr15_-_102019443 3.919 NM_144942
Csad
cysteine sulfinic acid decarboxylase
chr19_-_4877874 3.897 NM_013456
Actn3
actinin alpha 3
chr2_-_32137306 3.886 2900010J23Rik
RIKEN cDNA 2900010J23 gene
chr19_+_4855128 3.886 NM_019861
Ctsf
cathepsin F
chr2_-_104334728 3.845 Hipk3
homeodomain interacting protein kinase 3
chrX_+_130442964 3.819 NM_001083895
NM_026838
Srpx2

sushi-repeat-containing protein, X-linked 2

chr6_+_72548468 3.801 Retsat
retinol saturase (all trans retinol 13,14 reductase)
chr11_+_97702093 3.790 NM_001080935
B230217C12Rik
RIKEN cDNA B230217C12 gene
chr6_-_29559792 3.751 Tnpo3
transportin 3
chr18_-_14841254 3.746 Ss18
synovial sarcoma translocation, Chromosome 18
chr9_-_115219177 3.732 Stt3b
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr4_+_118906433 3.681 NM_001042411
Lepre1
leprecan 1
chr7_+_138087002 3.637 Htra1
HtrA serine peptidase 1
chr18_-_14841294 3.621 NM_001161369
NM_001161370
NM_001161371
NM_009280
Ss18



synovial sarcoma translocation, Chromosome 18



chr15_+_78858886 3.589 H1f0
H1 histone family, member 0
chr13_-_115892166 3.581 NM_001033228
Itga1
integrin alpha 1
chr6_-_126658429 3.571


chr15_+_58247107 3.563 D15Ertd621e
DNA segment, Chr 15, ERATO Doi 621, expressed
chr12_-_104970691 3.553 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr5_-_44485951 3.533 NM_001163578
NM_001163581
NM_001163582
NM_001163583
NM_001163584
NM_001163585
Prom1





prominin 1





chr15_-_74583382 3.527 NM_011838
Lynx1
Ly6/neurotoxin 1
chr17_+_64213350 3.398 Fert2
fer (fms/fps related) protein kinase, testis specific 2
chr8_-_114255972 3.387 NM_001198839
Bcar1
breast cancer anti-estrogen resistance 1
chr10_-_75130331 3.326 Cabin1
calcineurin binding protein 1
chr2_+_28061156 3.283 NM_001038612
NM_019498
Olfm1

olfactomedin 1

chr4_-_134828699 3.214 Clic4
chloride intracellular channel 4 (mitochondrial)
chr9_-_60535699 3.160 Lrrc49
leucine rich repeat containing 49
chr9_+_98325217 3.143 Rbp1
retinol binding protein 1, cellular
chr14_-_70919701 3.087 Bmp1
bone morphogenetic protein 1
chr10_-_70622370 3.047 NM_031397
Bicc1
bicaudal C homolog 1 (Drosophila)
chr2_+_174153230 3.027 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr5_+_31350991 3.022 NM_027855
0610007C21Rik
RIKEN cDNA 0610007C21 gene
chr9_-_115219553 3.013 Stt3b
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr3_+_121656136 3.000 NM_172525
Arhgap29
Rho GTPase activating protein 29
chr10_-_78054639 2.960 NM_027875
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr14_-_65716907 2.916


chr6_-_36759929 2.900 Ptn
pleiotrophin
chr7_-_135073508 2.878 Prss8
protease, serine, 8 (prostasin)
chr16_+_34995000 2.877 Mylk
myosin, light polypeptide kinase
chr18_-_12978106 2.869 Osbpl1a
oxysterol binding protein-like 1A
chr12_-_112615555 2.866 Cdc42bpb
CDC42 binding protein kinase beta
chr2_+_27532692 2.861 NM_011305
Rxra
retinoid X receptor alpha
chrX_+_137909951 2.813 NM_001163155
NM_007736
Col4a5

collagen, type IV, alpha 5

chr11_-_120504978 2.779 NM_144795
Pycr1
pyrroline-5-carboxylate reductase 1
chr15_-_34608458 2.768 NM_145469
Nipal2
NIPA-like domain containing 2
chr1_-_184397778 2.757 Capn2
calpain 2
chr7_-_35048648 2.754 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr15_+_54402988 2.743 Mal2
mal, T-cell differentiation protein 2
chr11_+_3414884 2.742 Selm
selenoprotein M
chr2_+_35159780 2.722 Gsn
gelsolin
chr17_+_46787285 2.653 NM_025611
Cul7
cullin 7
chr1_+_75503651 2.647 NM_010564
Inha
inhibin alpha
chr2_-_176194724 2.601 NM_001099349
0610010B08Rik
Gm14308
100043387
RIKEN cDNA 0610010B08 gene
predicted gene 14308
predicted gene, 100043387
chr11_+_3414686 2.591 NM_053267
Selm
selenoprotein M
chr2_+_119063090 2.588 NM_016907
Spint1
serine protease inhibitor, Kunitz type 1
chr5_-_45190857 2.580 NM_001077398
NM_010698
Ldb2

LIM domain binding 2

chr13_+_30228352 2.575 NM_153546
Mboat1
membrane bound O-acyltransferase domain containing 1
chr11_+_3414792 2.545 Selm
selenoprotein M
chr2_-_176097168 2.531 NM_001099327
0610010B08Rik
100043387
RIKEN cDNA 0610010B08 gene
predicted gene, 100043387
chr8_-_67212325 2.528 NM_025436
Sc4mol
sterol-C4-methyl oxidase-like
chr8_+_125927015 2.497 Tcf25
transcription factor 25 (basic helix-loop-helix)
chr3_+_145421870 2.489 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr8_+_36439713 2.486 Ppp1r3b
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr18_+_37644390 2.471 Pcdhb17
protocadherin beta 17
chr2_+_176493041 2.468 NM_001099327
0610010B08Rik
100043387
RIKEN cDNA 0610010B08 gene
predicted gene, 100043387
chr16_+_8513513 2.463 NM_001170978
NM_172961
Abat

4-aminobutyrate aminotransferase

chr7_+_149684731 2.418 NM_001163664
NM_001163665
NM_001163666
NM_001163667
NM_001163668
NM_001163669
NM_001163670
NM_011620
Tnnt3







troponin T3, skeletal, fast







chr19_-_57083064 2.410 NM_001177796
NM_001177797
NM_146102
Afap1l2


actin filament associated protein 1-like 2


chr15_-_81877947 2.408 NM_011482
Nhp2l1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr4_+_57580989 2.397 NM_172868
Palm2
paralemmin 2
chr2_-_127482430 2.386 NM_001171187
NM_010762
Mal

myelin and lymphocyte protein, T-cell differentiation protein

chr1_+_74283325 2.374 Arpc2
actin related protein 2/3 complex, subunit 2
chr9_+_45178267 2.317 NM_022004
Fxyd6
FXYD domain-containing ion transport regulator 6
chr4_+_151653120 2.314 Gpr153
G protein-coupled receptor 153
chr10_+_77441365 2.269 NM_026431
1810043G02Rik
RIKEN cDNA 1810043G02 gene
chrX_-_101176574 2.258 Rlim
ring finger protein, LIM domain interacting
chr14_+_63761507 2.257 Ctsb
cathepsin B
chr2_-_177575003 2.254 Gm2004
Gm14325
predicted gene 2004
predicted gene 14325
chr8_+_119028873 2.241 NM_029297
Dynlrb2
dynein light chain roadblock-type 2
chrX_+_71035158 2.232 Ssr4
signal sequence receptor, delta
chr13_-_101514515 2.216 NM_001190264
NM_025369
Mrps36

mitochondrial ribosomal protein S36

chr18_+_36446680 2.189 Pura
purine rich element binding protein A
chr10_+_18246228 2.187 Nhsl1
NHS-like 1
chr9_-_21116749 2.179 NM_001110300
NM_009678
Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr8_+_28233019 2.179 Gpr124
G protein-coupled receptor 124
chr8_-_8661060 2.175 Efnb2
ephrin B2
chr5_+_90890764 2.159 Alb
albumin
chr2_+_175964428 2.157 NM_001099349
0610010B08Rik
Gm14308
Gm4724
RIKEN cDNA 0610010B08 gene
predicted gene 14308
predicted gene 4724
chr11_+_89894863 2.147 Tmem100
transmembrane protein 100
chr17_-_27075896 2.143 Cuta
cutA divalent cation tolerance homolog (E. coli)
chr2_-_177691943 2.135 NM_001190302
Gm14326
predicted gene 14326
chr6_-_29559606 2.134 NM_177296
Tnpo3
transportin 3
chr16_+_34994935 2.125 Mylk
myosin, light polypeptide kinase
chr6_-_117887352 2.122 NM_001173372
NM_033648
Fxyd4

FXYD domain-containing ion transport regulator 4

chr16_-_17928207 2.117 Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr2_-_166774855 2.085 Stau1
staufen (RNA binding protein) homolog 1 (Drosophila)
chr9_-_56008828 2.079 NM_019793
Tspan3
tetraspanin 3
chr12_-_60112987 2.035 NM_009147
Sec23a
SEC23A (S. cerevisiae)
chr2_-_177813129 2.033 NM_001162922
Zfp931
zinc finger protein 931
chr11_-_116714173 2.022 Srsf2
serine/arginine-rich splicing factor 2
chr17_-_27076365 2.016 NM_026307
NM_026948
Cuta

cutA divalent cation tolerance homolog (E. coli)

chr11_-_69485842 1.996 NM_001159375
NM_144958
Eif4a1

eukaryotic translation initiation factor 4A1

chr10_+_127795461 1.987 Cs
citrate synthase
chr19_-_23522811 1.956 NM_174857
Mamdc2
MAM domain containing 2
chrX_-_91457942 1.920 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr9_+_118716348 1.914 Itga9
integrin alpha 9
chr5_+_67067477 1.906 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr10_+_115614313 1.899 NM_001161839
NM_001161838
NM_001161840
Ptprr


protein tyrosine phosphatase, receptor type, R


chr9_-_21116703 1.813 Ap1m2
adaptor protein complex AP-1, mu 2 subunit
chr1_+_120285634 1.808 NM_001081276
NM_029709
NM_177548
Clasp1


CLIP associating protein 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.78 9.71e-04 GO:0065008 regulation of biological quality
5.56 6.49e-03 GO:0006694 steroid biosynthetic process
2.13 7.80e-03 GO:0006629 lipid metabolic process
1.27 8.84e-03 GO:0008152 metabolic process
3.57 9.56e-03 GO:0008202 steroid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.46 1.30e-13 GO:0005737 cytoplasm
1.61 1.06e-12 GO:0044444 cytoplasmic part
1.30 1.03e-10 GO:0005622 intracellular
1.29 4.58e-09 GO:0044424 intracellular part
1.32 5.27e-08 GO:0043226 organelle
1.31 1.15e-07 GO:0043229 intracellular organelle
2.42 4.80e-07 GO:0005626 insoluble fraction
2.39 2.03e-06 GO:0005624 membrane fraction
2.11 1.00e-05 GO:0000267 cell fraction
1.28 5.97e-05 GO:0043227 membrane-bounded organelle
1.28 1.25e-04 GO:0043231 intracellular membrane-bounded organelle
1.12 4.55e-04 GO:0005623 cell
1.12 4.55e-04 GO:0044464 cell part
1.95 1.73e-03 GO:0005783 endoplasmic reticulum
1.90 2.69e-03 GO:0042995 cell projection
1.73 5.07e-03 GO:0005829 cytosol
1.68 1.38e-02 GO:0005739 mitochondrion
2.48 3.40e-02 GO:0044297 cell body
2.48 4.90e-02 GO:0043025 neuronal cell body

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.41 1.42e-05 GO:0005515 protein binding
1.21 1.23e-04 GO:0005488 binding
2.09 1.61e-03 GO:0019899 enzyme binding
2.15 4.04e-03 GO:0016491 oxidoreductase activity
1.30 2.72e-02 GO:0003824 catalytic activity